| MSCI | (1) X → A retrogenes with testis biased expression [2] | (2) Under-representation of male/testis-biased genes on the X [1] |
---|---|---|---|
MSCI as driving force (pros/cons) | Down-regulation of testis-specific insertions in the X. Use a single promoter [24, 29]. Down-regulation of X in meiosis. Use mixture of cells [25]. Down-regulation of X in wild-type testis as opposed to bam mutant testis [38]. bam mutant also show small degree of down regulation [31]. | Complementary expression in meiosis for X → A Retrogene [25]. | Under-representation of male-meiotic expressed genes in the X [25]. |
MSCI NOT as driving force (pros/ cons) | No global down regulation of the X chromosome in developing testis [32]. No statistical supporta. | Retrogenes with general female or unbiased expression [43]. No expression data support. | General tissue-specific under-representation on the X [32]. Tissue-specific genes are enriched with testis-biased genesa. |