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Table 2 Yeast genes comprising the Haploproficient Genome-Integrity (HPGI) set, along with their unique human orthologs, and functional annotations

From: Copy-number variation of cancer-gene orthologs is sufficient to induce cancer-like symptoms in Saccharomyces cerevisiae

Yeast gene

Unique human ortholog

Human ortholog function & OMIM cancer association (where applicable)

Yeast gene product cell cycle-related function

BUB2

-

-

Mitotic exit network regulator; blocks cell cycle progression before anaphase in response to spindle and kinetochore damage

CCR4

CNOT6

CCR4-NOT transcription complex, subunit 6

Component of the CCR4-NOT transcriptional complex

CDC34

UBE2R2

Ubiquitin-conjugating enzyme E2R 2

Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex that regulates cell cycle progression by targeting key substrates for degradation

CHK1

CHEK1

Serine/threonine kinase and DNA damage checkpoint effector

Serine/threonine kinase and DNA damage checkpoint effector

CLB1

CCNB1

Cyclin B1

B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase

CTF8

CHTF8

Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion

Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion

DBF2

-

-

Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis.

DNL4

LIG4

DNA ligase required for non-homologous end-joining; OMIM: Lig4 syndrome

DNA ligase required for nonhomologous end-joining (NHEJ)

IDP1

IDH1

Isocitrate dehydrogenase 1 (NADP+); OMIM: Oligodendroglioma; piloytic astrocytoma

Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate

IRR1

STAG1

Stromal antigen 1

Subunit of the cohesin complex, required for sister chromatid cohesion during mitosis and meiosis

MAD1

MAD1L1

Component of the spindle-assembly checkpoint

Coiled-coil protein involved in the spindle-assembly checkpoint; forms a complex with Mad2p

MEU1

MTAP

Methylthioadenosine phosphorylase; OMIM: Glioma

Methylthioadenosine phosphorylase

MLH1

MLH1

mutL homolog 1, colon cancer, nonpolyposis type 2

Protein required for mismatch repair in mitosis

MSH2

MSH2

mutS homolog 2, colon cancer, nonpolyposis type 1; OMIM: colorectal cancer

Protein required for mismatch repair in mitosis

MUS81

MUS81

MUS81 endonuclease homolog; OMIM: Bloom syndrome (predisposition to leukemias, lymphomas & carcinomas)

Subunit of the Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability

RAD1

ERCC4

Excision repair cross-complementing rodent repair deficiency, complementation group 4; OMIM: Xeroderma pigmentosum (predisposition to basal cell carcinoma & melanoma)

Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair

RAD54

RAD54L

RAD54-like; OMIM: Lymphoma, non-Hodgkin

DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; recombinational repair of double-strand breaks in DNA

RAD61

-

-

Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion

RAD9

RAD9

-

DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p

SMC2

SMC2

Structural maintenance of chromosomes 2

Subunit of the condensin complex

STP22

TSG101

Tumor susceptibility gene 101; OMIM: Breast cancer

Component of the ESCRT-I complex

TOP1

TOP1

Topoisomerase (DNA) I

Topoisomerase I

TOP2

TOP2B

Topoisomerase (DNA) II beta 180kDa

Topoisomerase II

TPD3

PPP2R1B

Protein phosphatase 2, regulatory subunit A, beta; OMIM: Lung cancer

Regulatory subunit A of the heterotrimeric protein phosphatase 2A (PP2A)

TUM1

TST

Thiosulfate sulfurtransferase (rhodanese); OMIM: Tumours

Rhodanese domain sulfur transferase

UBX4

ASPSCR1

Alveolar soft part sarcoma chromosome region, candidate 1; OMIM: Alveolar soft-part sarcoma

UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p

YCG1

NCAPG

non-SMC condensin I complex, subunit G

Subunit of the condensin complex

RIM11

GSK3A

Glycogen synthase kinase 3 alpha

Protein kinase required for signal transduction during entry into meiosis

NBP2

SH3GL1

SH3-domain GRB2-like 1; OMIM: Acute myeloid leukemia

Protein involved in the HOG (high osmolarity glycerol) pathway, contains an SH3 domain that binds Pbs2p

PBS2

MAP2K1

MAP kinase kinase

MAP kinase kinase of the HOG signaling pathway; mediates cell cycle arrest