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Table 4 Observed apoptotsis-related phenotypes of our HP yeast genes compared with those of their human orthologs

From: Copy-number variation of cancer-gene orthologs is sufficient to induce cancer-like symptoms in Saccharomyces cerevisiae

HP yeast gene

Human ortholog

Apoptotic phenotype (% dead cells) of yeast heterozygous deletion mutants treated with MMS. (Change in rate of apoptosis, relative to WT, is significant at p < 0.05 for all yeast heterozygotes.)

Mammalian apoptosis-related phenotype from literature

  

0.01% MMS

0.001% MMS

 

WT

-

79%

68%

 

CTF8

CHTF8

49%

-

-

MSH2

MSH2

56%

-

RNAi-mediated knockdown decreases apoptosis [25]

MUS81

MUS81

56%

-

-

TPD3

PPP2R1B

60%

-

RNAi-mediated knockdown decreases apoptosis [26]

TOP1

TOP1

55%

-

RNAi-mediated knockdown reduces nuclear apoptosis [27]

RAD54

RAD54L

44%

 

-

SMC3

SMC3

-

30%

RNAi-mediated knockdown increases apoptosis [28]

RAD1

ERCC4

-

22%

-

DNL4

LIG4

-

46%

Extensive apoptosis in mouse deletion homozygotes [29]

MAD1

MAD1L1

-

20%

-

MEU1

MTAP

-

94%

Pharmacological targeting of MTAP promotes apoptosis [30]

MLH1

MLH1

-

93%

Abnormal apoptosis (OMIM)

CHK1

CHEK1

-

82%

Blocking CHK1 induces apoptosis [31]

UBX4

ASPSCR1

-

80%

Regulator of apoptosis (OMIM)