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Figure 2 | BMC Biology

Figure 2

From: Drugging Hedgehog: signaling the pathway to translation

Figure 2

Small molecule manipulation of the Hh pathway. Major small molecule agonists (left) and antagonists (right) of Smoothened (center), and their clinical uses. Antagonists such as vismodegib (GDC-0449) and erismodegib (LDE225) are currently being trialed against a number of Hh pathway-activated cancers, whilst the two main agonists, SAG (Hh-Ag1.3) and purmorphamine, are being used for directed differentiation of stem cells to a variety of cell types.

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