POL2 allele | Mutation rates for different markers* | ||
---|---|---|---|
 | Forward mutation | Reversion | |
 |  | Base substitutions | Frameshifts (+1) |
 | Canr (× 10-7) | Ura+ × (10-8) | His+ × (10-8) |
Mismatch repair proficient strains | |||
wild-type | 3.3 | 1.3 | 1.1 |
 | 2.5–4.9 | 1.1–1.7 | 0.9–3.5 |
pol2-Y831A | 5.1 | 1.2 | 1.6 |
 | 3.5–12.1 | 0.8–2.8 | 0.5–2.7 |
pol2-4 | 27 | 3.41 | 452 |
 | 15–42 | 2.4–5.7 | 35–78 |
pol2-4,Y831A | 9 | 1.5 | 3.93 |
 | 7–15 | 1.1–1.9 | 2.3–5.4 |
Mismatch repair deficient strains (pms1) | |||
wild-type | 90 | 2.8 | 87 |
 | 72–150 | 2.4–4.1 | 54–150 |
pol2-Y831A | 340 | 124 | 4705 |
 | 230–420 | 11–19 | 270–790 |
pol2-4 | 760 | 1606 | 16007 |
 | 120–1060 | 90–420 | 950–2800 |
pol2-4,Y831A | 270 | 158 | 4109 |
 | 190–440 | 8–55 | 260–440 |