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Table 3 Effect of combining the exonuclease and active site mutations in DNA polymerase ε on mutation rates in diploids. Mismatch repair deficient strains (pms1/pms1)

From: Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations

Relevant mutation His+ reversion rate (× 10-8) Fold increase
+/+ 110 1
  90–140  
+/pol2-Y831A 400 4
  270–600  
pol2-Y831A/pol2-Y831A 820 7
  750–950  
+/pol2-4 1,500 14
  930–3600  
pol2-4/pol2-4 9,400 85
  5,900–14,000  
pol2-4/ pol2-Y831A 8,400 76
  3,500–17,000  
+/pol2-4,Y831A 210 2
  180–270  
pol2-4/pol2-4,Y831A 11,000 100
  8,100–22,000  
pol2-Y831A/pol2-4,Y831A 1,200 11
  1,030–1,460  
pol2-4,Y831A/pol2-4,Y831A 1,020 9
  840–2,300