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Figure 2 | BMC Biology

Figure 2

From: Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm

Figure 2

Effects of starvation on DAF-16 localisation and activity. (A-D) Images of live L1 larvae containing the muIs71 transgene expressing DAF-16a::GFP in a daf-16(mu86) background. Subcellular localisation of DAF-16a::GFP is clearest in the neurons of the nerve ring indicated by arrows. (A) fed larva, cytoplasmic and nuclear, (B) starved day 1, nuclear (C) starved day 2, cytoplasmic (with a characteristic "honeycomb" appearance) (D) age-1(hx546) starved day 2, nuclear (E) Quantification of the effect of prolonged starvation on DAF-16a::GFP localisation in wild type and age-1(hx546) L1 larvae. n= number of worms imaged. Number of independent experiments in brackets.

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BMC Biology

ISSN: 1741-7007

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