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Table 2 Summary of single marker association analyses with BSE status

From: A major genetic component of BSE susceptibility

  Frequency of Deletion P-Valuec Logistic Regression Analysis
23-bp indel Casesa (n) Controlsa (n)   P-Valued OR ins/dele OR del/dele PARf
UK Holstein 75.9 (363) 70.8 (276) 4.2 × 10-2 2.9 × 10-2 1.36 1.84 0.24
German Holstein 68.9 (127) 61.8b (335) 4.3 × 10-2 4.4 × 10-2 1.38 1.91 0.46
German Brown 53.5 (43) 34.5 (87) 3.3 × 10-3 5.4 × 10-3 4.74 4.62 0.69
German Fleckvieh 73.6 (106) 68.0 (136) 1.8 × 10-1 1.9 × 10-1 1.31 1.71 0.36
Combined   (639)   (834) 2.0 × 10-3 g 5.7 × 10-5 1.43 2.04  
12-bp indel          
UK Holstein 72.1 (350) 63.0 (270) 5.8 × 10-4 3.2 × 10-4 1.61 2.60 0.53
German Holstein 62.8 (125) 53.2b (357) 9.1 × 10-3 1.1 × 10-2 1.48 2.20 0.35
German Brown 32.6 (43) 14.4 (90) 5.9 × 10-4 1.1 × 10-2 4.01 3.65 0.44
German Fleckvieh 68.4 (106) 62.0 (137) 1.5 × 10-1 1.5 × 10-1 1.32 1.74 0.44
Combined   (624)   (854) 8.7 × 10-5 g 1.2 × 10-7 1.58 2.50  
  1. a Represents frequency (%) of deletion allele as calculated from genotypes; (n) indicates the number of individuals.
  2. b Control consists of half-sibs (see Additional File 1: Inferring allele, genotype, haplotype and diplotype frequencies from half-sibs).
  3. c P-values of χ2-test.
  4. d P-values from logistic regression, modelling the number of deletion alleles on BSE status.
  5. e Odds Ratios with reference genotype: ins/ins.
  6. f Population Attributable Risk: the portion of the BSE incidence in the population that is due to 12-bp deletion allele [15, 16].
  7. g P-Values of Fisher's Combined Probability test.