Skip to main content

Table 4 Summary of diplotype association analyses with BSE status

From: A major genetic component of BSE susceptibility

  No. of 12-bp Deletion Frequency of Diplotypes   
UK Holstein   Casesa (n) Controlsa (n) P-Valued ORe
23del-12ins/23del-12ins 0 0 (0) <1.0 (3) -  
23ins-12ins/23ins-12insc 0 3.7 (13) 4.8 (13) 4.8 × 10-1 1c
23del-12ins/23ins-12ins 0 1.7 (6) 5.1 (14) 1.4 × 10-2 0.45
23del-12ins/23del-12del 1 6.5 (23) 8.8 (24) 2.7 × 10-1 0.96
23ins-12ins/23del-12del 1 39.0 (139) 43.6 (119) 2.4 × 10-1 1.17
23del-12del/23del-12del 2 48.7 (172) 36.6 (100) 3.6 × 10-3 1.72
German Holstein        
23del-12ins/23del-12ins 0 <1.0 (1) <1.0 (3)b -  
23ins-12ins/23ins-12insc 0 7.8 (10) 15.3 (47)b 6.1 × 10-2 1c
23del-12ins/23ins-12ins 0 5.5 (7) 7.1 (22)b 6.0 × 10-1 1.48
23del-12ins/23del-12del 1 6.3 (8) 9.4 (29)b 2.4 × 10-1 1.18
23ins-12ins/23del-12del 1 39.1 (50) 40.6 (125)b 3.4 × 10-2 1.73
23del-12del/23del-12del 2 40.6 (52) 26.6 (82)b 1.2 × 10-2 2.54
German Brown        
23del-12ins/23del-12ins 0 2.4 (1) 3.3 (3) -  
23ins-12ins/23ins-12insc 0 14.3 (6) 45.6 (41) 3.7 × 10-4 1c
23del-12ins/23ins-12ins 0 26.2 (11) 25.6 (23) 9.6 × 10-1 3.12
23del-12ins/23del-12del 1 11.9 (5) 6.7 (6) 3.1 × 10-1 5.40
23ins-12ins/23del-12del 1 38.1 (16) 15.6 (14) 4.3 × 10-3 7.27
23del-12del/23del-12del 2 7.1 (3) 3.3 (3) - 6.38
German Fleckvieh        
23del-12ins/23del-12ins 0 <1.0 (1) 0 (0) -  
23ins-12ins/23ins-12insc 0 6.5 (7) 10.9 (15) 2.4 × 10-1 1c
23del-12ins/23ins-12ins 0 1.9 (2) 4.3 (6) - 0.79
23del-12ins/23del-12del 1 6.5 (7) 6.5 (9) 1 1.63
23ins-12ins/23del-12del 1 38.9 (42) 39.1 (54) 1 1.61
23del-12del/23del-12del 2 45.4 (49) 39.1 (54) 2.9 × 10-1 1.88
Combined        
23del-12ins/23del-12ins 0       
23ins-12ins/23ins-12insc 0       1c
23del-12ins/23ins-12ins 0       1.22
23del-12ins/23del-12del 1       1.70
23ins-12ins/23del-12del 1       2.10
23del-12del/23del-12del 2       2.86
  1. a Represents the frequency (%) of diplotypes; (n) indicates the number of individuals.
  2. b Calculated assuming Hardy-Weinberg equilibrium from haplotype frequency estimates (see Additional File 1: Inferring allele, genotype, haplotype and diplotype frequencies from half-sibs).
  3. c Diplotype taken as reference.
  4. d P-values from χ2-test against pooled observations of all remaining diplotypes.
  5. eOdds Ratios from logistic regression.