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Table 2 Sequence diversity in succinate dehydrogenase subunit genes

From: Sequence variation in human succinate dehydrogenase genes: evidence for long-term balancing selection on SDHA

Locus

Length (bp)*

Population

Sample size (n)†

S‡

Gene diversity ± SD

Nucleotide diversity, % (θ ± SD)

Nucleotide diversity, % (π ± SD)

FST (P§)

SDHA

5270

AA

24

35

0.974 ± 0.010

0.141 ± 0.045

0.231 ± 0.118

0.093 (0.012)

  

EA

24

27

0.903 ± 0.030

0.107 ± 0.036

0.147 ± 0.077

 
  

All

48

36

0.964 ± 0.009

0.126 ± 0.037

0.199 ± 0.101

 

SDHB

1722

AA

24

3

0.231 ± 0.078

0.039 ± 0.024

0.016 ± 0.019

0.061 (0.113)

  

EA

24

0

0

0

0

 
  

All

48

3

0.120 ± 0.045

0.034 ± 0.021

0.008 ± 0.013

 

SDHC

1813

AA

24

8

0.680 ± 0.060

0.086 ± 0.040

0.103 ± 0.067

0.176 (~0)

  

EA

24

2

0.082 ± 0.053

0.012 ± 0.012

0.013 ± 0.017

 
  

All

48

8

0.441 ± 0.061

0.075 ± 0.033

0.065 ± 0.046

 

SDHD

2036

AA

24

5

0.609 ± 0.063

0.055 ± 0.028

0.077 ± 0.052

0.234 (~0)

  

EA

24

0

0

0

0

 
  

All

48

5

0.361 ± 0.059

0.048 ± 0.024

0.044 ± 0.034

 
  1. AA, African American samples; EA, European American samples; SD, standard deviation.
  2. *Includes coding and non-coding sequences.
  3. †Number of unrelated subjects.
  4. ‡Number of segregating sites.
  5. §p value for population genetic structure between AA and EA.