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Figure 8 | BMC Biology

Figure 8

From: Platypus globin genes and flanking loci suggest a new insertional model for beta-globin evolution in birds and mammals

Figure 8

Loci flanking vertebrate α-globin (A) and β-globin (B) clusters. The relative locations of flanking loci (A) MPG, C16orf35, LUC7L and GBY and (B) RRM1, CCKBR, ILK and ORG genes were searched for beside the α-β globin cluster in zebrafish (Danio rerio) and frog (Xenopus tropicalis), and beside the separate α-globin and β-globin clusters in chicken (Gallus gallus), opossum (Monodelphis domestica) and human (Homo sapiens) from Ensembl [57]. The pufferfish (Fugu rubripes) flanking loci shown here were adapted from Gillemans et al. [8]. For the platypus, the α-globin flanking loci were characterised in this study, and ORG genes surrounding the platypus β-globin cluster were discovered: however, the BAC clone (484F22) was too small to cover the region containing the loci RRM1, CCKBR and ILK. In X. tropicalis LUC7L was found on another scaffold (466 from Ensembl) but sequence analyses by Fuchs et al. [2] suggested that LUC7L resides 3' to the frog α-β-GBY cluster. The flanking loci as well as the α- and β-globin clusters are differentiated by colour.

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