Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay

Table 6 K _a/K _s ratios comparison between human nonsense-mediated mRNA decay and Non-nonsense-mediated mRNA decay concatenated alignments.

	NMD-specific exon alignment^a	Remained region in NMD alignment^a	Non-NMD-single exon alignment^b	Remained region in Non-NMD alignment^b
ω (Human)	0.3423	0.2627	0.2554	0.1668
ω(Mouse)	0.1082	0.2184	0.1835	0.128
ω(Dog)	0.0884	0.2509	0.2193	0.1676

Notes. NMD = nonsense-mediated mRNA decay. ω (Human), ω (Mouse) and ω (Dog) are the K _a/K _s ratios in human, mouse and dog lineages, respectively. ^a NMD-specific exon alignment was concatenated alignment from the human NMD-specific exon regions of human-mouse-dog three-way CDS alignments, and the rest regions in the CDS alignments were concatenated together to construct the remained NMD alignment. ^b similar to the NMD-specific case, the human non-NMD-single exon regions of human-mouse-dog three-way CDS alignments were clipped out to construct the concatenated alignment, and the rest regions to construct the remained non-NMD alignment. See Methods for details.

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