Skip to main content

Table 7 Test of neutral evolution for human nonsense-mediated mRNA decay-specific exons under branch model.

From: Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay

Model

ω (Human)

ω (Mouse)

ω (Dog)

Log-likelihood

Number of parameters

P value

Free-ratios

0.3423

0.1082

0.0884

-6947.6716

7

 

Free-ratios(fix)

1

0.0973

0.0732

-6963.5371

6

1.77E-08

  1. Note: if the neutral evolution occurred in human lineage, then the log-likelihood should not change much after the ω is fixed at 1. Our data reject this neutral model with a significant difference.