Figure 8

Deregulation of stress-response, proliferation and differentiation pathways in serum-starved Art^Δ/Δ MSCs. (a) Difference in RFC (ΔRFC) between WT and Art^Δ/Δ cells (defined as [WT RFC] - [Art^Δ/Δ RFC]) was determined for the 157 genes identified in Figure 7a. Plotted are data for all genes showing ΔRFC = 2 or greater. Positive ΔRFC values indicate a higher RFC in WT than in Art^Δ/Δ samples; conversely, negative ΔRFC values denote lower RFC in WT than in Art^Δ/Δ samples. Individual gene names are indicated. (b) RFC for genes in (a) are indicated, with WT (dark fill) and Art^Δ/Δ (light fill) data overlaid. Genes with gene ontology (GO) annotations in BMP/WNT signaling, or in other growth factor signaling, are indicated by red/green (WT/Art^Δ/Δ) or blue/orange (WT/Art^Δ/Δ) shading, respectively. (c-e) RFC data for genes with GO annotations for stress response (c), cell proliferation (d), or cell differentiation (e) are shown. RFC for each gene in WT (gray bars) and Art^Δ/Δ (open bars) samples are overlaid. Individual gene names are indicated. Genes with in BMP, WNT or growth factor signaling pathways are highlighted in red.