Haploinsufficiency and the sex chromosomes from yeasts to humans

Table 1 Phylogenetic relationships of the Ascomycete fungi

Class	Species	P value of increased HI orthologue retention
Saccharomycetes:
Post-WGD yeasts	Saccharomyces cerevisiae	-
	Saccharomyces paradoxus	0.002
	Saccharomyces bayanus	0.001
	Kluyveromyces polysporus	0.01
	Saccharomyces castellii	0.009
Pre-WGD yeasts	Saccharomyces kluyveri	0.04
	Kluyveromyces waltii	0.004
	Ashbya gossypii	0.003
	Kluyveromyces lactis	0.001
	Candida albicans	0.01
	Candida tropicalis	0.001
	Candida parapsilosis	0.0004
	Lodderomyces elongisporus	0.0006
	Candida lusitaniae	0.001
	Debaryomyces hansenii	0.006
	Candida guilliermondii	0.001
	Yarrowia lipolytica	0.02
Eurotiomycetes	Aspergillus nidulans	0.0009
Sordariomycetes	Neurospora crassa	0.0005
	Magnaporthe grisea	0.03
Schizosaccharomycetes	Schizosaccharomyces pombe	0.01
	Schizosaccharomyces japonicus	0.001

The P value for Saccharomyces cerevisiae haploinsufficient (HI) genes having a greater likelihood of having an orthologue, relative to the genome average, is shown for each species. Ribosomal protein genes were excluded from the analysis (see main text).
WGD = whole-genome duplication.

ISSN: 1741-7007