Figure 2From: Expression of constitutively active erythropoietin receptor in pyramidal neurons of cortex and hippocampus boosts higher cognitive functions in miceEssentially normal basic behavior of cEPOR TG mice contrasts the distinctly superior cognitive performance. TG mice were normal in basic behavioral functions (A - E) except for slight hyperactivity, as demonstrated by increased velocity in the open field (inset B). In basic cognitive tasks, that is spatial learning/memory and cognitive flexibility as evaluated by Morris water maze (F - H) and social memory (I), cEPOR TG mice were significantly superior to WT. WT n = 18; TG n = 13; mean ± SEM presented. Insets in F: within - day learning on day one of the hidden platform task: all four trials presented; probe trial expressed as % of time spent in target quadrant; Inset in H: within-day learning on day one of the reversal task: all four trials presented.Back to article page