Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets

Table 1 Name of datasets analyzed for each figure

Figure Name	Analyzed library
Figure 1A	GSM416733
Figure 1B	GSM416733
Figure 2A	GSM416733	HEK293
	GSM416753	HeLa
	GSM416754	U2OS
	GSM416755	143B
	GSM416756	A549
	GSM416757	H520
	GSM416758	SW480
	GSM416759	DLD2
	GSM416760	MCF7
	GSM416761	MB-MDA231
Figure 2B	GSM314552	Mouse-Esc
	GSM416732	Mouse-MEF
	GSM466487	Drosophila
	GSM604032	C.elegans
	GSM775340	S.cerevisiae
	GSM757894	S.pombe
	GSM1208316	R.sphaeroides
Figure 2C	GSM510432toGSM510435	Ovary
	GSM51043toGSM510439	Testes
	GSM510440toGSM510444	Brain
	GSM510445toGSM510456	Newborn
	GSM510457toGSM510460	E12.5
	GSM510465toGSM510468	E7.5
	GSM314552	ESC
Figure 3A-B	GSM416733	HEK293
Figure 4A-B	GSM314552	ESC_WT
	GSM314553	ESC_dcr--
	GSM314557	ESC_dgcr8--
Figure 4C-D	SRR029028	WT
	SRR029029	dcr-1
	SRR029030	dcr-2
Figure 4E	GSM466487	WT
	GSM466492	dcr-2
	GSM466496	r2d2
Figure 4F	GSM757894	WT
Figure 4F	GSM757897	dcr
Figure 4G	SRR207111	Whole-cell
Figure 4G	SRR207116	Nucleus
Figure 5A	GSM545212	AGO1
	GSM545213	AGO2
	GSM545214	AGO3
	GSB545215	AGO4
Figure 5B	GSM545212, GSM545213, GSM545214 and GSB545215 combined
Figure 5C	GSM545212 dataset and the 17,319 CCRs reported in Hafner et al. [36].
Figure 6	GSM1219487, GSM1219488, GSM1219489, GSM1219490, GSM1219491, GSM1219492 combined
Figure 7	GSM1219487, GSM1219488, GSM1219489, GSM1219490, GSM1219491, GSM1219492 combined

ISSN: 1741-7007