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Figure 1 | BMC Biology

Figure 1

From: Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

Figure 1

Proteotoxic crisis in cancer cells. (A) In normal cells, the natural load of degradation substrates on the left is in balance with the capacity of the cellular ubiquitin-proteasome system (UPS), signified by the proteasome on the right. (B) In cancer cells, the load is increased due to expression of mutant proteins and/or expression of excess proteins due to aneuploidy. This results in an imbalance where the degradation load exceeds the capacity of the UPS.

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