Figure 3
From: Cell lineage branching as a strategy for proliferative control
Control strategies and layered architectures. (A) Lineage branching allows for different control strategies, depending on how the probabilities of differentiation and replication are regulated. Any strategy with a positive regulation of p r is unstable. Negative feedback on all the probabilities is unrealizable because the probabilities must add up to 1. Any strategy implementing negative feedback on p r and positive feedback on p d is akin to renewal control. The last strategy, which implements positive feedback on p a with simultaneous negative feedback on p r and p d , is free from the limitations described in the text. We refer to this feedback strategy as fate control. (B) Multi-layer cell lineage with renewal control strategy. (C) Multi-layer cell lineage with a fate control strategy. Red lines represent negative feedback regulation, and green arrows represent positive feedback regulation.