Skip to main content
Fig. 5 | BMC Biology

Fig. 5

From: Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development

Fig. 5

Dynamic changes in cell proliferation of Apc CKO lung. a-b Increased DNA synthesis, measured by EdU incorporation, in mesenchymal cells was found in lungs of Apc CKO mice at E11.5 (a-b), while decreased EdU labeling was observed in both epithelial and mesenchymal cells in Apc CKO lungs after E12.5. c-d Increased EdU incorporation persisted to E13.5 in lung mesenchyme when constitutively active Ctnnb1 (or Ctnnb1 Δex3) was expressed in mice with genotypes of Tbx4-Cre ERT/Ctnnb1 fx-ex3/+ plus tamoxifen induction at E10.5. a, c: Tissue immunofluorescence staining; b, d: quantitative analyses of the immunostained cells. Ep: epithelial cells, Me: mesenchymal cells. *P < 0.05, n = 4

Back to article page

BMC Biology

ISSN: 1741-7007

Contact us