Skip to main content
Fig. 5 | BMC Biology

Fig. 5

From: Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body

Fig. 5

The phase and amplitude of PER2 rhythms in central tissues is influenced by photoperiod. a Double-plotted rhythms in PER2 expression were measured with immunohistochemistry for the subdivisions of the septum [medial septum (MS), lateral septum (LS)] and hippocampus (CA1, CA3, Dentate Gyrus, Hilus) under LD12:12 (blue symbols) and LD20:4 (red symbols). White and black bars on the abscissa represent lighting conditions. n = 4–6/time-point/photoperiod. * LD12:12 versus LD20:4, LS Means Contrasts, P <0.006. Cosinor analyses of PER2 rhythms are shown in Additional file 1: Table S4. b Summary plots of photoperiodic changes in the phase of central tissues. Tissues are ordered by the magnitude of the difference in peak time. Dashed vertical lines indicate the magnitude of the shift displayed by the SCN shell and SCN core in vivo, as detected with PER2 immunohistochemistry (c.f., Additional file 1: Table S4). * Significant phase difference, one sample t-test, P <0.05

Back to article page