Fig. 8

Ligand-induced bone formation in vivo. Quantification of the ossified surface areas induced by the indicated amounts of ligands doped on the implanted insoluble collagenous bone matrix cylinders. The data represent mean values of explants from at least five individual animals. a Orthotopic model (calvaria); b heterotopic model (hind-limb muscle). For statistics, see Additional file 8: Table S2 and Additional file 9: Table S3