Fig. 5
From: Using mathematical models to understand metabolism, genes, and disease
Stability of extracellular dopamine against genetic variation. Homeostasis of dopamine to variation in the activities of TH and DAT. The wild type is indicated by the large white circle. The positions of homozygotes and heterozygotes for the seven mutations from Table 1 are indicated by small white circles. The alleles are assumed to act additively. Most of the mutations lie in the relatively flat region of the landscape. After [26, 34]