Fig. 4
Rescaled and renormalized data. a Individual clone populations (here, peripheral blood mononuclear cells of animal RQ5427) show significant fluctuations in time. For clarity, only clones that reach an appreciable frequency are plotted. b The corresponding normalized clone size distributions at each time point are rescaled by the sampled and marked fraction of blood, ν=q/S×f, where q is the number of reads of a particular clone within the sample. After an initial transient, the fraction of clones (dashed curves) as a function of relative size remains stable over many years. For comparison, the dot-dashed gray curves represent binomial distributions (with S=103 and 104 and equivalent mean clone sizes) and underestimate low population clones