Fig. 3

GSTFs have different genetic interactions. a Hierarchical clustering of GSTF pairs based on their epistatic effects. Average linkage clustering was applied to group GSTF pairs with similar epistatic effects. The identity of genes was disregarded. Instead, the number of total occurrences for each of the six different epistatic effects (Fig. 2a) were used. Similarities between GSTF pairs were calculated based on cosine correlation. Colored branches depict example groups described in the text. GSTFs marked with a diamond have DNA binding domains of the same type. The number of epistatic effects underlying the clustering are shown as bar-plots below the dendrogram (colors as in Fig. 2a). GSTF pairs with epistatic effects on less than ten genes are not included in the clustering, but are shown on the right. b Number of non-epistatic expression changes. Dark grey for the first named GSTF, light grey for the second. Counted are all genes with significantly changed expression (P ≤0.01) above a FC of 1.5. Left-to-right ordering as in a. c Growth-based genetic interaction scores depicted by solid circles. Significant scores are visualized in black, grey otherwise. Vertical lines for visual purpose only. Left-to-right ordering as in a