Fig. 5
From: Nuclear fallout provides a new link between aPKC and polarized cell trafficking
aPKC recycling in the epithelial cells. Schematic model of aPKC transport to the membrane in Rab11-Nuf RE vesicles (left): (1) Vesicles derived from the RE (REdv) containing aPKC move to the apico-lateral site via Rab11-Nuf. (2) aPKC interacts with the apical complexes and becomes active. (3) Active aPKC is able to interact with and phosphorylate Nuf. This phosphorylation release aPKC-Nuf interaction (red dash-line box on the right) (4) inhibiting its apico-lateral localization. aPKC atypical PKC, RE recycling endosome, Nuf nuclear fallout