Table 3 Enrichment of functional classes among 278 Nipi genes
From: A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes
Category/Phenotype upon RNAia | Number over-lapping genes | Total number genes in class | Percentage of MAPK signaling genes in class | Probabilityb |
|---|---|---|---|---|
1. Conserved in D. melanogaster c as described in [124] | 169 | 3710 | 84.8 | 3.77 × 10−54 |
2. Stimulate microbial aversion behaviorc [26] | 65 | 374 | 33.3 | 1.39 × 10−50 |
3. Suppress over-expression of gpdh-1p::gfp seen in osm-8 mutantc,d [72] | 52 | 252 | 24.2 | 7.87 × 10−44 |
4. Decrease acdh-1p::gfp expression [73] | 35 | 146 | 6.1 | 3.33 × 10−31 |
5. Induce hsp-6p::gfp (mitochondrial UPR) [66] | 30 | 95 | 0.0 | 1.60 × 10−30 |
6. Protein expression [125] | 43 | 446 | 9.1 | 1.18 × 10−21 |
7. Required for cytoprotective response – four different reporter genesc [49] | 21 | 71 | 24.2 | 3.08 × 10−20 |
8. Required for transgene silencing [57] | 50 | 823 | 24.2 | 1.25 × 10−16 |
10. Alter RAB-11 sub-cellular localization and transport of the apical membrane protein PEPT-1 [79] | 34 | 426 | 15.2 | 3.40 × 10−14 |
11. Synthetic phenotype with lin-35 [126] | 27 | 252 | 6.1 | 3.95 × 10−14 |
12. Required for mitochondrial surveillance and response [74] | 14 | 45 | 9.1 | 2.08 × 10−13 |
13. Regulators of gpdh-1 expressiond [75] | 18 | 123 | 6.1 | 2.45 × 10−11 |
15. Aberrant GFP::PGL-1 phenotypes [76] | 20 | 170 | 12.1 | 6.87 × 10−11 |
16. Suppressors of polyglutamine aggregation [77] | 19 | 173 | 9.1 | 9.65 × 10−10 |
17. Mitochondrial [125] | 17 | 160 | 0.0 | 2.35 × 10−8 |
18. Upregulated after 12 h of dauer recovery [127] | 44 | 1175 | 12.1 | 3.31 × 10−7 |
20. Altered expression in zpf-1 mutant [128] | 21 | 333 | 3.0 | 2.24 × 10−6 |
21. Down regulated in an ogt-1 mutant [129] | 30 | 670 | 9.1 | 4.02 × 10−6 |
22. Altered expression in rde-4 mutant [128] | 17 | 232 | 6.1 | 7.17 × 10−6 |
23. Induce hsp-70p::gfp [130] | 9 | 52 | 9.1 | 1.03 × 10−5 |
8 | 42 | 9.1 | 2.79 × 10−5 | |
25. Increase longevity [133] | 9 | 66 | 3.0 | 8.78 × 10−5 |
26. Induced after 24 h of D. coniospora infection (cDNA microarrays) [2] | 21 | 419 | 12.1 | 1.12 × 10−4 |
27. Confer hypoxia-resistance [134] | 14 | 198 | 9.1 | 1.98 × 10−4 |
29. Induce irg-1p::gfp [59] | 10 | 102 | 0.0 | 4.37 × 10−4 |
31. Energy generation [125] | 10 | 104 | 3.0 | 5.23 × 10−4 |