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Table 5 Foundling Nipi genes

From: A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes

Gene/sequence name

Brief description

dcar-1

GPCR receptor; activated by HPLA [20]

elo-2

Palmitic acid elongase; ELO-2 is required with ELO-1 for 20-carbon PUFA production

frpr-11

GPCR of the FMRFamide Peptide Receptor family; unlike dcar-1, acts downstream of gpa-12 and blocks osmotic induction of nlp-29 [20]

ins-6

Predicted type-beta insulin-like peptide

mltn-12

MLt-TeN (mlt-10) related; MLT-10 is a nematode-specific protein required for ecdysis

nas-37

Astacin-class metalloprotease required for ecdysis; N-terminal signal sequence followed by an Astacin protease domain and three protein-binding domains (EGF-like, CUB, and thrombospondin)

srsx-25

GPCR of the serpentine receptor class SX

srv-21

GPCR of the serpentine receptor class V; unlike dcar-1, acts downstream of gpa-12 and blocks osmotic induction of nlp-29 [20]

sta-2

STAT family of transcription factor [7]

F56A8.5

Protein containing an F-box

K08C9.5

Protein containing an F-box

C33D9.3

Nematode-specific

F27C8.2a

Nematode-specific

F27C8.3a

Nematode-specific

F34H10.1

Ubiquitin/40S ribosomal protein S27a fusion protein

K08C9.7

Ubiquitin/40S ribosomal protein S27a fusion protein

R186.8

39S ribosomal protein L33, mitochondrial

T08D2.2b

Similar to C-terminal half of UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase

T08D2.6b

YIPF4-like; YIPF4, poorly characterized membrane spanning protein; in yeast, interacts with Rab GTPases

Y60A3A.19

YIPF4-like.;YIPF4, poorly characterized membrane spanning protein; in yeast, interacts with Rab GTPases

C42C1.3

Nematode-specific

F35F10.14

Nematode-specific

F41H8.1c

Nematode-specific domain: GPCR of the serpentine receptor class BC

K09C6.6c

Nematode-specific domain: GPCR of the serpentine receptor class BC

K09C6.10c

Nematode-specific

F42C5.9

Actin

F45E4.5

Nematode-specific

F49H12.5

Thioredoxin domain-containing protein 12-like

F52C6.13

Nematode-specific

tsen-54

N-terminal half similar to that of tRNA-splicing endonuclease subunit Sen54

Y39G10AR.7

Nematode-specific

Y51H7BR.7

Contains Spec3 domain, like Drosophila Stumbled

Y67D8C.22

Clarin-like

  1. a,bTargeted by a single mv clone
  2. cPotential targets of the same sjj clone
  3. References are given for genes previous connected to the regulation of nlp-29 expression; see Additional file 7: Table S6