Fig. 4
From: Evolutionary origin and functional divergence of totipotent cell homeobox genes in eutherian mammals
Evidence for function from sequence and expression. a Heatmaps showing placental mammal phastCons conservation probability scores for the coding sequences of human CRX and ETCHbox genes; from 0 (blue) to 1 (red). The most consistent conserved (red) stretch codes for homeodomain helix 3. b Heatmaps showing expression profiles in developmental stages and adult tissues of human ETCHbox genes compared to paralogues OTX2 and CRX, and stem cell markers, according to fragments per kilobase per million reads (FPKM) on a log2 scale (red, high expression; blue, low expression). c Heatmaps showing expression profiles in developmental stages and adult tissues of cow ETCHbox genes, according to FPKM on a log2 scale (red, high expression; blue, low expression)