Fig. 2

SAXS analysis of wild-type (WT) and pTyr371-N-Cbl. a Top: WT experimental scattering data (dark red) versus theoretical scattering curve from crystal structure (PDB:2Y1M) before (dashed green line; χ = 2.05) and after normal modes refinement (solid red line; χ = 0.94). Bottom: pTyr371-N-Cbl experimental scattering data (orange) versus theoretical scattering from the EOM 2.0 ensemble (orange line; χ = 0.77). b P(r) distribution of WT (solid red) and pTyr371-N-Cbl (dashed orange). c Normalized Kratky plot of WT and pTyr371-N-Cbl coloured as in (a). d EOM 2.0 distributions of the random pool (black) and the ensembles of WT and pTyr371-N-Cbl coloured as in (b)