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Table 3 Average ensemble outcome R g and D max from EOM 2.0 together with the χ value and the quantification of flexibility (R flex) for each N-Cbl variant

From: Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation

N-Cbl variant

R g (nm)

D max (nm)

Fit (χ value)

R flex (%)

Y371F

2.38

7.67

1.284

56

WT

2.41

7.89

0.831

60

Y368F

2.46

8.37

0.778

65

M222E

2.44

8.05

1.030

65

Y371H

2.44

8.24

0.695

69

Y371A

2.52

8.16

1.020

75

Y371S

2.61

8.89

0.774

84

Y371D

2.64

8.91

0.814

88

Y371E

2.79

9.43

0.773

90