Fig. 6From: Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemiaMechanism underlying chemoresistant ALL driven by mutations in NT5C2. Mutations located either in the vicinity of helix A or at the oligomerization sites induce misregulation of cN-II activity through conformational modulation of the oligomeric interface, which boosts the viability of tumor cells during chemotherapyBack to article page