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Fig. 2 | BMC Biology

Fig. 2

From: Angiopoietin 2 signaling plays a critical role in neural crest cell migration

Fig. 2

Time-lapse analysis reveals a multistep sequence to the neural crest and endothelial cell interactions in r4. Transverse (a) and dorsal (b) view of neural crest cells migrating away from the neural tube in stereotypic patterns and endothelial cells moving in the opposite direction towards the neural tube. Schematics at top outline the multistep sequence of migration: 1, endothelial cell cluster near the dorsal aorta; 2, as neural crest cells pass the dorsal aorta, the endothelial cells sprout and migrate alongside the neural crest stream; 3, the endothelial cells connect with the plexus around the neural tube. The images below are of the same embryo time-lapse images shown from a transverse (a) and dorsal (b) view at indicated elapsed times of H2B-mCherry labeled neural crest (magenta) and H2B-YFP endothelial cells (green). White circle (0 h 0 min) highlights visible portion of dorsal aorta where endothelial cells will sprout. Colored circles indicate individual endothelial cells to aid in visual tracking between frames and views of the time lapse. Scale bar 50 μm

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