Fig. 6

Gain and loss of Ang2 in neural crest disrupt the type of motion neural crest cells exhibit. a Example MSD curves for cells undergoing one type of motion during an entire time lapse. Random diffusion (D, straight line), directed motion (V, parabola), and confined diffusion (C, asymptotic). b Mean MSD curves for neural crest migrating in vivo that have been electroporated with indicated vector. Control: 10 embryos and 246 cells, Ang2-FL: 8 embryos and 118 cells, Ang2-shRNA: 4 embryos and 55 cells. While each curve is parabolic over short time intervals, the behavior deviates from a single-shaped curve over longer time intervals. c Bayesian analysis of in vivo neural crest MSD curves. Each cell was assigned to be in the front 30% of the stream or trailing 70%. Then the front or trailing MSD curves were analyzed by the MSD-Bayes analysis package. The probability of each type of motion is shown by the size of the bar