Fig. 2

Genetic interactions link intergenic SUTs to diverse biological processes. a Heatmap of gene ontology (GO) terms enriched by genes whose deletions result in negative genetic interactions. The synthetic genetic array (SGA) procedure was performed for TLC1, EST1 and six intergenic SUTs. The negative genetic interaction (NGIs) from the different SGA screens were analysed as described in Methods to identify enriched GO terms with P ≤ 0.05 (generated using Fisher exact test). b and c Heatmap of GO terms enriched by genes classified as having a NGI with TLC1 (b), SUT457 (c) or their corresponding flanking genes. The NGIs of the genes flanking the tested lincRNAs were extracted from the Drygin database (http://drygin.ccbr.utoronto.ca/) and Szappanos et al. [53]