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Fig. 7 | BMC Biology

Fig. 7

From: MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging

Fig. 7

Schematic model of miR-29 action in brain aging. During aging an accumulation of iron in neurons occurs. This induces expression of miR-29 that in turn represses expression of IRP-2 thereby limiting iron uptake. This mechanism counteracts aging-related damages. MiR-29 may also counteract effects aging-related phenotypes by additional mechanisms, for example modulation of pro-apoptotic BCL-2 family members [21, 22]

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BMC Biology

ISSN: 1741-7007

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