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Fig. 7 | BMC Biology

Fig. 7

From: Functional studies of Drosophila zinc transporters reveal the mechanism for zinc excretion in Malpighian tubules

Fig. 7

Tubule-specific inhibition of Zip71B and ZnT35C suppresses the formation of tubule stones. Representative tubule images taken from different groups of flies. Scale bars = 200 μm. Tubule-specific RNAi of Xdh resulted in significantly increased tubule stone formation compared to controls. Knockdown of Zip71B or ZnT35C in Malpighian tubules significantly suppressed the stone formation, while knockdown of dZnT1 or ZnT41F displayed no obvious fly stone reduction. Genotypes of the flies are NP1093-GAL4/+ (control fly), Xdh-RNAi/+; NP1093-GAL4/+ (Xdh-RNAi fly), ZnT35C-RNAi/+; Xdh-RNAi/+; NP1093-GAL4/+ (Xdh-RNAi ZnT35C-RNAi fly), dZnT1-RNAi/+; Xdh-RNAi/+; NP1093-GAL4/+ (Xdh-RNAi dZnT1-RNAi fly), ZnT41F-RNAi/+; Xdh-RNAi/+; NP1093-GAL4/+ (Xdh-RNAi ZnT41F-RNAi fly), Zip71B-RNAi/+; Xdh-RNAi/+; NP1093-GAL4/+ (Xdh-RNAi Zip71B-RNAi fly)

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