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Fig. 8 | BMC Biology

Fig. 8

From: Functional studies of Drosophila zinc transporters reveal the mechanism for zinc excretion in Malpighian tubules

Fig. 8

A model for zinc excretion in Drosophila Malpighian tubules. Zinc homeostasis in Drosophila Malpighian tubules is mediated by a set of plasma membrane-resident zinc transporters. Zip71B (dZip5) is localized to the basolateral membrane of tubule cells and responsible for zinc import from the body into Malpighian tubules. ZnT35C is localized to the apical membrane of tubule cells and pumps zinc out into tubule lumen. Zip71B/dZip5 and ZnT35C act in concert for moving zinc across the tubule cells in zinc excretion. dZnT1 is localized to the basolateral membrane of tubule cells and functions in zinc reabsorption to recover zinc from excretion. The transcription of Zip71B/dZip5 and ZnT35C is subject to the regulation of zinc ion

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