Fig. 7

Matriptase zymogen conversion is required for normal whisker and pelage hair development. a Representative examples of the outward appearance of 1-month-old St14 ^+/+ mice (left) and St14 ^zym/zym littermates (right). b Delayed pelage hair eruption in St14 ^zym/zym mice. Representative example of two St14 ^zym/zym pups and two wildtype littermates at day 6. c Loss of matriptase zymogen conversion causes whisker defects. Representative examples of whiskers from St14 ^+/+ (top panels) mice and St14 ^zym/zym (bottom panels) littermates at birth (0 days), 4 days, 10 days, and 6 weeks. St14 ^zym/zym mice display short, curly, and kinked whiskers