Fig. 6.From: Tissue macrophages: heterogeneity and functionsGut macrophages populate the lamina propria and the myenteric plexus and interact with the microbiome and immune cells as well as the epithelium, smooth muscle and nerves. a Lamina propria macrophages in the mouse small intestine express abundant F4/80 antigen, indicated by arrows. The T-cell-rich Peyer’s patch and dome epithelium (stars) in the centre of the micrograph are devoid of F4/80 expression. Intestinal lumen, asterisks. From [114], ©Hume et al., 1983. Originally published in The Journal of experimental medicine. http://0-doi-org.brum.beds.ac.uk/10.1084/jem.158.5.1522. b Schematic representation of intestinal cross section to show interactions of macrophages (blue) with myenteric and autonomic nervous system projections (green). The inset shows the nerve ending releasing neurotransmitter which is recognized by β2 adrenergic receptors (β2AR) on the macrophage. From [54], reprinted from Cell, 164, Gabanyi I, Muller PA, Feighery L, Oliveira TY, Costa-Pinto FA, Mucida D, Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages, 378,©2016, with permission from ElsevierBack to article page