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Table 6 Simple TMHs are less similar than complex TMHs to TMHs from multi-pass proteins in ExpAll

From: Charged residues next to transmembrane regions revisited: “Positive-inside rule” is complemented by the “negative inside depletion/outside enrichment rule”

Residues

P values for χ2

Bahadur slopes for χ2

Simple-vs-complex

Simple-vs-multi

Complex-vs-multi

Simple-vs-complex

Simple-vs-multi

Complex-vs-multi

 R

5.10E-06

2.98E-01

5.10E-06

9.17E-03

1.61E-03

6.23E-05

 K

2.35E-03

1.85E-01

2.35E-03

4.81E-03

3.88E-03

9.78E-05

 D

2.61E-08

1.84E-01

2.61E-08

4.15E-02

7.90E-03

1.41E-04

 E

2.38E-10

2.04E-01

2.38E-10

3.88E-02

7.08E-03

1.22E-04

 Y

3.03E-01

3.11E-01

3.03E-01

2.01E-03

2.49E-03

5.51E-05

 W

4.21E-03

4.29E-01

4.21E-03

1.11E-02

4.76E-03

6.46E-05

 L

3.79E-01

3.04E-01

3.79E-01

2.28E-04

4.66E-04

1.50E-05

 C

3.87E-01

2.52E-01

3.87E-01

1.75E-03

3.28E-03

1.48E-04

 R + K

7.16E-04

2.52E-01

7.16E-04

2.80E-03

1.28E-03

3.76E-05

 D + E

3.58E-05

2.94E-01

3.58E-05

1.03E-02

1.94E-03

4.90E-05

 

P values for Kolmogorov-Smirnov

Bahadur slopes for Kolmogorov-Smirnov

 

Simple-vs-complex

Simple-vs-multi

Complex-vs-multi

Simple-vs-complex

Simple-vs-multi

Complex-vs-multi

 R

3.61E-01

4.31E-02

3.61E-01

7.66E-04

7.79E-03

1.62E-04

 K

4.31E-02

8.93E-01

4.31E-02

2.49E-03

1.05E-02

6.57E-06

 D

1.39E-01

2.18E-03

1.39E-01

4.68E-03

3.61E-02

5.10E-04

 E

5.31E-01

1.33E-04

5.31E-01

1.11E-03

2.81E-02

6.87E-04

 Y

2.31E-01

9.06E-04

2.31E-01

2.47E-03

6.26E-03

3.30E-04

 W

5.31E-01

4.98E-03

5.31E-01

1.29E-03

1.13E-02

4.04E-04

 L

2.31E-01

2.31E-01

2.31E-01

3.45E-04

2.12E-03

1.85E-05

 C

5.31E-01

3.61E-01

5.31E-01

1.16E-03

8.91E-04

1.09E-04

 R + K

1.39E-01

2.31E-01

1.39E-01

7.61E-04

4.82E-03

4.00E-05

 D + E

1.39E-01

9.06E-04

1.39E-01

1.99E-03

1.41E-02

2.80E-04

 

P values for Kruskal-Wallis

Bahadur slopes for Kruskal-Wallis

 

Simple-vs-complex

Simple-vs-multi

Complex-vs-multi

Simple-vs-complex

Simple-vs-multi

Complex-vs-multi

 R

4.37E-01

3.92E-01

4.37E-01

6.24E-04

2.52E-03

4.82E-05

 K

3.83E-01

6.93E-01

3.83E-01

7.62E-04

2.88E-03

2.13E-05

 D

4.49E-01

1.81E-01

4.49E-01

1.90E-03

1.06E-02

1.42E-04

 E

7.64E-01

1.94E-01

7.64E-01

4.71E-04

9.05E-03

1.26E-04

 Y

8.32E-01

3.36E-01

8.32E-01

3.09E-04

9.63E-04

5.15E-05

 W

7.25E-01

1.36E-01

7.25E-01

6.53E-04

5.44E-03

1.52E-04

 L

7.15E-01

7.95E-01

7.15E-01

7.90E-05

3.41E-04

2.90E-06

 C

8.47E-01

9.54E-01

8.47E-01

3.05E-04

4.26E-05

5.06E-06

 R + K

2.89E-01

5.13E-01

2.89E-01

4.79E-04

1.41E-03

1.82E-05

 D + E

4.94E-01

2.07E-01

4.94E-01

7.11E-04

4.14E-03

6.29E-05

  1. As in Table 5, the statistical results were gathered by comparing complex single-pass TMHs, simple TMHs from single-pass proteins and TMHs from multi-pass proteins; however, in this case only ExpAll is used. The abundance of different residues at each position when using the centrally aligned TMH approach was compared with several statistical tests (Kolmogorov-Smirnov, Kruskal-Wallis and the χ2 statistical tests) and the Bahadur slope values of those results