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Fig. 7 | BMC Biology

Fig. 7

From: Multiple essential functions of Plasmodium falciparum actin-1 during malaria blood-stage development

Fig. 7

A model visualising the intracellular functions of PfACT1 during P. falciparum asexual stages (upper panels) and the corresponding phenotypes when PfACT1 function is disrupted (lower panels). 1. Apicoplast (green) migration requires the presence of PfACT1 filaments (grey dotted lines, upper panel), failing which they collapse around the FV (lower panel). 2. PfACT1 is required to separate daughter cells in the final stages of cytokinesis (upper panel). In the absence of PfACT1, conglomerates of merozoites are observed, indicating a role for actin in normal daughter merozoite formation (lower panel). 3. Invasion of the host erythrocyte requires the presence of PfACT1 in released daughter merozoites (upper panel). In the absence of PfACT1, the merozoite attaches, reorients but is abrogated in its ability to invade the host cell (lower panel)

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