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Table 1 Human autosomes with common trisomies, in ascending order of number of ohnologs

From: Dosage-sensitive genes in evolution and disease

Human chromosome number

Number of dosage-balanced ohnologsa

Trisomy syndrome

Frequency (number of live births)b

21

61

Down's

1/700

18

98

Edward's

1/5000

13

138

Patau

1/16,000

  1. aIdentified from gene trees in Ensembl v86 [109] as genes that duplicated at the base of the vertebrate tree with no subsequent SSD
  2. bFrequency data from [90] and ghr.nlm.nih.gov/trisomy-18; ghr.nlm.nih.gov/trisomy-13