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Fig. 3 | BMC Biology

Fig. 3

From: Early life diet conditions the molecular response to post-weaning protein restriction in the mouse

Fig. 3

Molecular changes to variant-specific rDNA methylation response to protein restriction are restricted to pre-weaning exposure. a In sperm, percentage of rDNA copies with an A at position −104 bp (%A) does not correlate with percentage of those A copies with methylation at CpG −133 (CpG –133 A meth %) in CTCT (black, n = 17, n Litters  = 10, cor = −0.25, adjusted P lin  = 0.99). b %A in CTPR (blue, n = 17, n Litters  = 11, cor = −0.59, adjusted P lin  = 0.15). c %A correlates positively with CpG –133 A meth % in PRCT (orange, n = 16, n Litters  = 9, cor = 0.5, adjusted P lin  = 0.0008). d There was no correlation between %A and CpG –133 A meth % in PRPR (red, n = 14, n Litters  = 10, cor = −0.14, adjusted P lin  = 0.99). Pearson’s product moment correlation coefficients are given and a linear model was run to assess the relationship in group with sibling relatedness being accounted for using robust standard errors. P values are adjusted for n = 4 tests using Bonferroni’s method

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