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Fig. 6 | BMC Biology

Fig. 6

From: Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress

Fig. 6

REDD1 deletion increases basal metabolism in vivo. a Basal whole-body O2 and CO2 fluxes in young (2 months) and adult mice (12 months; n = 6 per group). b Global and immobile voluntary activity (n = 14 per group). c Food intake (n = 14 per group). d Rectal temperature measured at 22 °C in 5–6-month-old WT (n = 8) and KO mice (n = 9). e Body (n = 10 per group), white adipose tissue (WAT; WT n = 8 and KO n = 7), kidney (WT n = 6 and KO n = 7), spleen (n = 6 per group), tibialis anterior muscle (TA; n = 8 per group), gastrocnemius muscle (GAS; n = 8 per group), soleus muscle (SOL; WT n = 10 and KO n = 9), and quadriceps muscle (QUAD; WT n = 7 and KO n = 6) weight in 12–13-month-old WT and REDD1 KO mice. *p < 0.05, **p < 0.01 and ***p < 0.001 vs. corresponding WT group by unpaired t-test. Black bars are CTRL WT and open bars are CTRL KO. CTRL control, GAS gastrocnemius, KO knockout, mo month, QUAD quadriceps, RER respiratory exchange ratio, SOL soleus, TA tibialis anterior, WAT white adipose tissue, WT wild type

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