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Fig. 5. | BMC Biology

Fig. 5.

From: Towards a Dynamic Interaction Network of Life to unify and expand the evolutionary theory

Fig. 5.

Workflow of the evolutionary analysis of interaction networks. From left to right: triangles represent components of interaction networks, edges between triangles represent interactions between these components. Interaction networks are first constructed/inferred, then their nodes and edges are colored to produce evolutionary colored networks (ECNs) that represent both the topological and the evolutionary properties of the networks. ECNs can be investigated individually by graph decomposition and centrality analyses, or several ECNs can be compared by graph alignment. The two types of comparisons can return conserved subgraphs that allow understanding of the dynamics of interaction networks, meaning when different sets of interactions (hence processes) evolved, and whether these interactions were evolutionarily stable. Ancient and Contemporary refer to the relative age of the sub-graphs, identifying new clade-specific relationships (here called refinement); introgression indicates that a component, and the relationship it entertains with the rest of the network, was inferred to result from a lateral acquisition

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