Fig. 4
From: Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins
Screens for machinery involved in the degradation of IMS proteins. a Summary heat map of the screens for components of the ubiquitin-proteasome system that are involved in the degradation of the indicated tFT-tagged IMS proteins. Changes in protein stability (z-scores) are color-coded from blue (decrease) to red (increase). Only mutants that significantly affected the stability of at least one tFT-tagged protein (5% false discovery rate and |z-score| > 4) are shown. b Volcano plot of the screen results with Cox12-tFT, with z-scores for changes in protein stability on the x-axis and the negative logarithm of p values adjusted for multiple testing on the y-axis. 19S proteasome mutants are represented by filled circles