Fig. 7
From: VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX
Concomitant expression of WWOX and VOPP1 in human breast tumors. a The 448 breast cancer patients were classified into two groups (low WWOX (< 0.6), n = 193; and high WWOX (≥ 0.6), n = 255), and the proportion of tumors expressing high (≥ 2.5) or low levels (< 2.5) of VOPP1 was assessed in each group. Statistical significance was calculated by the chi-square test (b). Kaplan-Meier curves showing metastasis-free survival rates of patients with tumors expressing high (red line) vs. low (blue line) VOPP1/WWOX ratio in subpopulations of patients with low or high WWOX levels. c Multivariate Cox proportional hazards analysis showing the independence of the VOPP1/WWOX expression ratio in the prognosis of breast cancer patients retaining WWOX expression (HR, hazard ratio; CI, confidence interval)