Skip to main content
Fig. 7 | BMC Biology

Fig. 7

From: Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

Fig. 7

ATFS-1-regulated genes involved in stress resistance and metabolism are required for the long lifespan of nuo-6 mutants. To explore the contribution of genes that show an ATFS-1-dependent upregulation in nuo-6 mutants, we decreased the expression of these genes in nuo-6 worms. We found that decreasing the expression of hsp-6 (a), gst-4 (b), sodh-1 (e), cdr-2 (h), ldh-1 (i), or acs-2 (k) using RNAi did not decrease the lifespan of nuo-6 worms. In contrast, hif-1 mutation (c), mtl-1 RNAi (d), sod-3 mutation (f), fmo-2 RNAi (g), and aldo-1 RNAi (j) significantly reduced nuo-6 longevity. This indicates that changes in gene expression induced by the activation of the mitoUPR contribute to the long-lifespan of nuo-6 worms. Significance between red and purple lines is indicated. See Additional file 4: Table S4 for raw lifespan data. See Additional file 5: Table S5 for details on N and replicates

Back to article page