Fig. 7

Relationship between bilateral founder domains, cell differentiation, and otx-six3/6 expression. a Schematic representation of the bilateral founder domains at 32 hpf with a color code reflecting bilateral symmetry (compare to Fig. 5A’). b Schematic representation of the bilateral founder domains color-coded by quadrant homology (compare to Fig. 5D). c A summary diagram of the types of symmetry in the episphere. The bilateral founder pairs are color-coded by the type of symmetry behavior (left panel) and their clonal domains at 32 hpf. d Bilateral founder cells originate at different time points during development, highlighted by the temporal color-coding of their clonal domains. Note that the peripheral areas (dark and light blue) are the first to adopt the bilateral behavior. The areas along the dorso-ventral axis (yellow, red, and white) are the last ones to adopt bilateral behavior. e The position of differentiated cell types (compare to Fig. 3F) within the bilateral founder domains. f The overlay of the otx and six3/6 expression and the bilateral founder domains at 32 hpf